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GPRASP1 Antibody

  • 中文名稱：
    GPRASP1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA009848GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    GPRASP1
  • 別名：
    G-protein coupled receptor-associated sorting protein 1 antibody; GASP antibody; GASP-1 antibody; GASP1 antibody; GASP1_HUMAN antibody; Gprasp1 antibody; KIAA0443 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Human GPRASP1-Specific
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.
  • 基因功能參考文獻(xiàn)：
    1. Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1 PMID: 25706089
    2. Data suggest that specific serine/threonine residues in DRD2 (dopamine receptor D2) are involved in regulation of DRD2 endocytosis by GRK2 (G-protein coupled receptor kinase 2) and GASP1. PMID: 23082996
    3. GASP1 was identified as a potential new serum and biomarker for brain, pancreatic, lung, and breast cancers, and gliomas. PMID: 22483848
    4. LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression. PMID: 21900845
    5. These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer. PMID: 21791203
    6. following this endocytosis the D(3) dopamine receptors fail to recycle and are instead targeted for degradation through an interaction with the G protein-coupled receptor (GPCR)-associated sorting protein-1 (GASP-1) PMID: 21030592
    7. This review describes the discovery of GASPs, their major features, interacting partners, functions and possible involvement in pathological situations including neurodegenerative diseases and cancer. PMID: 20394773
    8. identified a protein that binds preferentially to the cytoplasmic tail of the delta opioid receptor as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor-associated sorting protein (GASP) [GASP] PMID: 12142540
    9. Modulation of the D2-GASP interaction is important for the functional down-regulation of D2 dopamine receptors. PMID: 16049099

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    GPRASP family
  • 組織特異性：
    Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24834

    OMIM: 300417

    KEGG: hsa:9737

    STRING: 9606.ENSP00000355146

    UniGene: Hs.729265