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  4. GRIK4 Antibody, HRP conjugated

GRIK4 Antibody, HRP conjugated

  • 中文名稱：
    GRIK4兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA619054LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GRIK4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    EAA 1 antibody; EAA1 antibody; Excitatory amino acid receptor 1 antibody; GluK4 antibody; Glutamate receptor antibody; Glutamate receptor ionotropic kainate 4 antibody; Glutamate receptor ionotropic kainate 4 precursor antibody; Glutamate receptor KA 1 antibody; Glutamate receptor KA 1precursor antibody; Glutamate receptor KA-1 antibody; Glutamate receptor KA1 antibody; Glutamate receptor; ionotropic kainate 4 antibody; GRIK 4 antibody; GRIK antibody; Grik4 antibody; GRIK4_HUMAN antibody; ionotropic kainate 4 antibody; KA 1 antibody; KA1 antibody; OTTHUMP00000045951 antibody; OTTHUMP00000231881 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Glutamate receptor ionotropic, kainate 4 protein (826-956AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
  • 基因功能參考文獻(xiàn)：
    1. the GRIK4 polymorphisms genotypes were distributed as follows: rs79526501: CC696: 16, CG302: 274, GG31: 35; rs11218016: CC455: 483, CT473: 436, TT101: 108; and rs6589847: AA32: 29, AG307: 314, GG690: 686. However, there was no significant difference in allelic or genotypic frequency distributions between patients and controls. We did not find any significant association between GRIK4 polymorphisms and schizophrenia. PMID: 28658089
    2. Results firstly indicated that rs56275759 of GRIK4 gene might be associated with major depressive disorder in Chinese Han population. PMID: 28583584
    3. This study showed the lower GluK4 mRNA levels in pregnant women. PMID: 28284346
    4. Data suggest the involvement of glutamate receptor, ionotropic, kainate 4 protein (GRIK4) in treatment-resistant depression (TRD) and in the risk of developing psychotic symptoms during depressive episodes. PMID: 26139080
    5. Subjects possessing the C allele or CC genotype of the GRIK4 polymorphism rs1954787 are more likely to respond to antidepressant treatment. PMID: 25303296
    6. The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells. PMID: 22052594
    7. Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation and immunoglobulin production. PMID: 21215464
    8. The GRIK4 single nucleotide polymorphism (rs12800734) shows a strong association with disease remission in antidepressant treatment. PMID: 19924111
    9. Cytogenetic and genetic findings provide molecular evidence for common etiologies for schizophrenia and and bipolar disorder and further support the 'glutamate hypothesis' of psychotic illness. PMID: 16819533
    10. An insertion/deletion (indel) variant in the 3' untranslated region (3'UTR) of the GRIK4 gene in subjects carrying the protective bipolar disorder haplotype was found. PMID: 18824690
    11. This report provides the first evidence that genetic variation in the GRIK4 gene modulates hippocampal function. PMID: 19384319

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK4 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4582

    OMIM: 600282

    KEGG: hsa:2900

    STRING: 9606.ENSP00000404063

    UniGene: Hs.538738