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GTF2E2 Antibody

  • 中文名稱：
    GTF2E2兔多克隆抗體
  • 貨號：
    CSB-PA010003LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: GTF2E2 antibody at 2µg/ml
      Lane 1: Mouse brain tissue
      Lane 2: Hela whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Lane 4: PC-3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 34 kDa
      Observed band size: 34 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GTF2E2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GTF2E2
  • 別名：
    FE antibody; General transcription factor IIE subunit 2 antibody; General transcription factor IIE; polypeptide 2; beta 34kDa antibody; gtf2e2 antibody; T2EB_HUMAN antibody; TF2E 2 antibody; TF2E2 antibody; TFIIE B antibody; TFIIE-beta antibody; Transcription initiation factor IIE beta subunit antibody; Transcription initiation factor IIE subunit beta antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Transcription initiation factor IIE subunit beta protein (1-291AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，GTF2E2 Antibody (CSB-PA010003LA01HU)，的標(biāo)記方式是Non-conjugated。對于GTF2E2 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA010003LB01HU GTF2E2 Antibody, HRP conjugated ELISA
    FITC CSB-PA010003LC01HU GTF2E2 Antibody, FITC conjugated
    Biotin CSB-PA010003LD01HU GTF2E2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
  • 基因功能參考文獻(xiàn)：
    1. functional analysis of Trichothiodystrophy causative TFIIEbeta mutation demonstrates that mutant TFIIEbeta strongly reduces the total amount of the entire TFIIE complex, with a remarkable temperature-sensitive transcription defect. PMID: 28973399
    2. We underline role of TFIIE in transcription and its distinction from nucleotide excision repair. Trichothiodystrophy individuals with mutations in GTF2E2 highlight the importance of the direct interaction between TFIIH and TFIIE in transcription process. PMID: 26996949
    3. PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta. PMID: 25308091
    4. introduced point mutations into two regions located near the carboxy terminus of TFIIE beta and identified the functionally essential amino acid residues that bind to RNA polymerase II PMID: 12665589
    5. TFIIE is an alpha/beta heterodimer in solution; A model for the quaternary architecture of the complex is proposed that provides a structural framework to discuss the function of TFIIE in the context of RNA polymerase II transcription initiation. PMID: 16547462
    6. These data suggest a model in which TFIIE binds to a position adjacent to the initiation site via the forkhead domain, enabling TFIIH to begin opening the promoter. PMID: 19210545

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  • 相關(guān)疾?。?/div>
    Trichothiodystrophy 6, non-photosensitive (TTD6)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    TFIIE beta subunit family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4651

    OMIM: 189964

    KEGG: hsa:2961

    STRING: 9606.ENSP00000348168

    UniGene: Hs.77100