HBZ Antibody

^{Rare Species}

說明書

產(chǎn)品詳情

Uniprot No.：

P0C745
基因名：

HBZ
別名：

HTLV-1 basic zipper factor (HBZ) HBZ
反應種屬：

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)
免疫原：

Recombinant Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) HBZ protein (1-209aa)
免疫原種屬：

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Affinity-chromatography
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Enhances viral infectivity and persistence, and facilitates proliferation of HTLV-1-infected lymphocytes. Mechanistically, inhibits Tax-mediated viral replication and NF-kappa-B activation. Plays a role in allowing infected T-cells to escape the cytotoxic T-lymphocyte response by maintaining low levels of viral protein production. Inhibits also host EP300 histone acetyltransferase (HAT) activity, reducing levels of acetylated histone H3 at 'Lys-18' (H3K18ac) in infected cells. Contributes to the accumulation of chromosomal abnormalities by inhibiting double-stranded DNA breaks (DSB) repair through the NHEJ pathway. Participates in the modulation of host immune response at multiple levels contributing to abnormal interferon signaling and viral pathogenesis.
亞細胞定位：

Host nucleus.
蛋白家族：

HTLV-1 HBZ protein family