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  4. HERC5 Antibody, FITC conjugated

HERC5 Antibody, FITC conjugated

  • 中文名稱：
    HERC5兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA883435LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HERC5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HERC5
  • 別名：
    CEB1 antibody; CEBP1 antibody; Cyclin E binding protein 1 antibody; Cyclin-E-binding protein 1 antibody; E3 ISG15--protein ligase HERC5 antibody; HECT domain and RCC1 like domain containing protein 5 antibody; HECT domain and RCC1-like domain-containing protein 5 antibody; Hect domain and RLD 5 antibody; HECT E3 ubiquitin ligase antibody; HERC5 antibody; HERC5_HUMAN antibody; Herc6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ISG15--protein ligase HERC5 protein (153-284AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
  • 基因功能參考文獻(xiàn)：
    1. Low HERC5 expression is associated with HIV infections. PMID: 29669830
    2. A synonymous mutation at rs6857425 (T-C) was present in the same region among all study groups (T-C), irrespective of their HIV status. PMID: 28737979
    3. Results show that HERC5 mediates covalent ISG15 conjugation to parkin in mammalian cells and that ISG15 is conjugated to the Lys349 and Lys369 residues of parkin. PMID: 27534820
    4. HERC5 plays a crucial role in HCC immune evasion and has clinical relevance as a reproducible prognostic marker for risk of tumor recurrence and survival in patients. PMID: 26653219
    5. The inhibitory effect of ISG15 on HCV RNA replication does not require its conjugation to substrates by HERC5. PMID: 26361997
    6. vIRF1 association with HERC5 altered ISG15 modification of cellular proteins, and knockdown of ISG15 augmented reactivation of KSHV from latency. PMID: 26355087
    7. The study reports on the NMR solution structure of a G-quadruplex formed by the CEB1 DNA G-rich fragment d(AGGGGGGAGGGAGGGTGG), harboring several G-tracts including one with six continuous guanines. PMID: 24742225
    8. Results show that HERC5 gene may be involved in regulating the spread of non-small cell lung cancer tumors where the methylation of its promoter is correlated with number increase of disseminated tumor cells and metastases as well as survival decreased. PMID: 25353388
    9. Authors identified a second distinct mechanism by which HERC5 inhibits HIV-1 replication and demonstrate that HERC5 is evolving under strong positive selection. PMID: 24693865
    10. Data indicate that income was inversely related to smoking behavior, and paternally derived CEB1 mutations were dose dependently increased when the father smoked in the 6 mo before pregnancy, 0.21 vs. 0.05 in smoking and nonsmoking fathers, respectively. PMID: 23538710
    11. The E3 ligase activity of HERC5 was required for blocking HIV-1 Gag particle production and correlated with the post-translational modification of Gag with ISG15. PMID: 22093708
    12. This study characterizes HERC5 as a positive regulator of innate antiviral responses, and show that it sustains IRF3 activation via a novel posttranslational modification, ISG15-ylation. PMID: 20308324
    13. Data show that HERC5, a functionally active HECT ubiquitin ligase, exhibits a tightly controlled cytosolic level under inflammatory conditions in endothelial cells. PMID: 15331633
    14. HERC5/Ceb1 is involved in the conjugation of ISG15 to cellular proteins. PMID: 16815975
    15. these results suggest that Herc5 functions as a general E3 ligase for protein ISGylation. PMID: 16884686
    16. Overexpression of cyclin E is associated with neuroendocrine lung tumors PMID: 17471231

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  • 亞細(xì)胞定位：
    Cytoplasm, perinuclear region. Note=Associated with the polyribosomes, probably via the 60S subunit.
  • 組織特異性：
    Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24368

    OMIM: 608242

    KEGG: hsa:51191

    STRING: 9606.ENSP00000264350

    UniGene: Hs.26663