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  4. HES6 Antibody

HES6 Antibody

  • 中文名稱：
    HES6兔多克隆抗體
  • 貨號(hào)：
    CSB-PA788871
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HeLa cells, using HES6 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HES6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HES6
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from N-terminal of Human HES6.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.
  • 基因功能參考文獻(xiàn)：
    1. High HES6 expression is associated with metastasis in colorectal cancer. PMID: 30015909
    2. prostate cancer-specific up-regulation of NOTCH3 and HES6, is reported. PMID: 25864518
    3. HES6 mutations are associated with castration resistant and androgen independent tumors in prostate cancer. PMID: 25006183
    4. HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1. PMID: 24737870
    5. HES6 contributes to the pathogenesis of alveolar rhabdomyosarcoma by enhancing both proliferation and cell motility. PMID: 22982728
    6. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. PMID: 21785461
    7. Data suggest that Hes-6 is a potential oncogene overexpressed in breast cancer, with a tumor-promoting and proliferative function. Hes-6 is a novel estrogen-regulated gene in breast cancer cells. PMID: 19891787
    8. Differentially expressed in metastatic colon carcinoma PMID: 12957362
    9. Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity. PMID: 12972610
    10. Here, we show that WRPW motif deletion mutant Hes6 protein is substantially stabilized in comparison to the full length protein and that the enhanced stability is due to its resistance to proteasomal degradation. PMID: 15896295
    11. Hes6 overexpression using a retroviral vector led to a decrease in Hes1 levels, an increase in beta-cell transcription factors and partial restoration of insulin expression PMID: 17300753
    12. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. PMID: 17301032
    13. ATOH1 activates HES6 transcription through binding to three clustered E boxes of its promoter PMID: 17826772
    14. the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and -independent pathways. PMID: 18160400
    15. These four variants were tested for association with mood disorder diagnosis or antidepressant response in a family study of depression, but no significant associations were observed. PMID: 19481584

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  • 亞細(xì)胞定位：
    Nucleus.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18254

    OMIM: 610331

    KEGG: hsa:55502

    STRING: 9606.ENSP00000272937

    UniGene: Hs.42949