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HINFP Antibody

  • 中文名稱：
    HINFP兔多克隆抗體
  • 貨號：
    CSB-PA010361LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Rat liver tissue
      All lanes: HINFP antibody at 4.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 60, 49 kDa
      Observed band size: 60 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) HINFP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HINFP
  • 別名：
    DKFZp434F162 antibody; HiNF-P antibody; HINFP antibody; HINFP_HUMAN antibody; Histone H4 gene specific protein HiNF P antibody; Histone H4 transcription factor antibody; Histone nuclear factor P antibody; MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein antibody; MBD2 interacting zinc finger 1 antibody; MBD2 interacting zinc finger protein antibody; MBD2-interacting zinc finger protein antibody; Methyl CpG binding protein 2 interacting zinc finger protein antibody; Methyl-CpG-binding protein 2-interacting zinc finger protein antibody; MIZF antibody; ZNF743 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human Histone H4 transcription factor protein (370-515AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，HINFP Antibody (CSB-PA010361LA01HU)，的標記方式是Non-conjugated。對于HINFP Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA010361LB01HU HINFP Antibody, HRP conjugated ELISA
    FITC CSB-PA010361LC01HU HINFP Antibody, FITC conjugated
    Biotin CSB-PA010361LD01HU HINFP Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
  • 基因功能參考文獻：
    1. purified and functionally characterized the critical transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family PMID: 14585971
    2. These results suggest that transcriptional repression of Rb by MIZF could be one of the critical determinants in myogenic differentiation. PMID: 15541338
    3. HiNF-P interacts directly with p220(NPAT) to coactivate histone genes during S phase. PMID: 15988025
    4. the transcriptional silencing of the 14-3-3sigma gene is caused by promoter CpG island methylation associated with MBD2, which may play an important role in prostate cancer progression during the invasive and metastatic stages of the disease PMID: 16786000
    5. These results suggest that RFP is a mediator connecting several MBD proteins and allowing the formation of a more potent transcriptional repressor complex. PMID: 17049487
    6. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. PMID: 17163457
    7. HiNF-P-dependent stabilization of p220NPAT reinforces signaling through the cyclin E/CDK2/p220NPAT pathway and contributes to coordinate control of histone gene expression. PMID: 17176114
    8. HiNF-P/P220NPAT regulates expression of nonhistone targets that influence competency for cell cycle progression. PMID: 17974976
    9. a novel HiNF-P-specific conserved region represents a DNA-binding determinant that plays a role in mediating histone gene expression during the cell cycle and defines HiNF-P as a cell cycle regulatory member of the zinc finger transcription factor family PMID: 18850719
    10. Results suggest that cyclin-dependent kinase inhibitors selectively control stimulation of the histone H4 gene promoter by the p220(NPAT)/HiNF-P complex. PMID: 19170105

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  • 亞細胞定位：
    Nucleus. Note=Associated with discrete nuclear foci.
  • 組織特異性：
    Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.
  • 數據庫鏈接：

    HGNC: 17850

    OMIM: 607099

    KEGG: hsa:25988

    STRING: 9606.ENSP00000318085

    UniGene: Hs.504091