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HOXB2 Antibody

  • 中文名稱：
    HOXB2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA106653
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from LOVO cells, A549 cells, HUVEC cells and MCF-7 cells, using HOXB2 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) HOXB2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    HOXB2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human HOXB2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能參考文獻(xiàn)：
    1. HOXB2 and HOXB3 act as tumor suppressors in acute myeloid leukemia patients carrying the FLT3 protein mutations. PMID: 26482852
    2. Increased expression of HOXB2 protein is associated with HPV infection and cervical cancer progression. PMID: 25743797
    3. HOXB2 acts as a negative tumor growth regulator, decreasing proliferation in mammary adenocarcinoma tumors. PMID: 21672623
    4. hoxb2 and hoxb4 expression is related to erythroid hematopoiesis, and hoxb4 has greater relevance to erythroid hematopoiesis as compared with hoxb2. PMID: 20030938
    5. Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation. PMID: 20625746
    6. Hoxb2 is a direct target for regulation by PLZF in the developing CNS and suggest that deregulation of Hox gene expression may contribute to APL pathogenesis. PMID: 12802276
    7. HOXB2 up-regulated lesions to have much higher HOXB2 expression than the corresponding normal tissue. PMID: 17805056

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Proboscipedia subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 5113

    OMIM: 142967

    KEGG: hsa:3212

    STRING: 9606.ENSP00000331741

    UniGene: Hs.514289