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HSD17B11 Antibody

  • 中文名稱：
    HSD17B11兔多克隆抗體
  • 貨號：
    CSB-PA000765
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using 17β-HSD11 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    HSD17B11
  • 別名：
    17 beta HSD 11 antibody; 17 beta HSD XI antibody; 17 BETA HSD11 antibody; 17 BETA HSDXI antibody; 17 beta hydroxysteroid dehydrogenase 11 antibody; 17 beta hydroxysteroid dehydrogenase type XI antibody; 17 beta hydroxysteroid dehydrogenase XI antibody; 17-beta-HSD 11 antibody; 17-beta-HSD XI antibody; 17-beta-hydroxysteroid dehydrogenase 11 antibody; 17-beta-hydroxysteroid dehydrogenase XI antibody; 17betaHSD11 antibody; 17betaHSDXI antibody; 17bHSD11 antibody; CTCL associated antigen HD CL 03 antibody; CTCL tumor antigen HD CL 03 antibody; CTCL-associated antigen HD-CL-03 antibody; Cutaneous T cell lymphoma associated antigen HD CL 03 antibody; Cutaneous T-cell lymphoma-associated antigen HD-CL-03 antibody; Dehydrogenase/reductase SDR family member 8 antibody; DHB11_HUMAN antibody; DHRS8 antibody; Estradiol 17 beta dehydrogenase 11 antibody; Estradiol 17-beta-dehydrogenase 11 antibody; Hsd17b11 antibody; Hydroxysteroid (17 beta) dehydrogenase 11 antibody; PAN1B antibody; Retinal short chain dehydrogenase/reductase 2 antibody; Retinal short-chain dehydrogenase/reductase 2 antibody; RETSDR2 antibody; SDR16C2 antibody; SDR2 antibody; Short chain dehydrogenase/reductase family 16C member 2 antibody; T cell lymphoma associated antigen HD CL 03 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human 17β-HSD11.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
  • 基因功能參考文獻：
    1. knowledge of its in vitro activity together with a newly described expression pattern at the protein level in tissues involved in steroidogenesis and detoxification could suggest a potential role of DHRS8 in vivo PMID: 26472732
    2. hydroxysteroid (17-beta) dehydrogenase 11 transcription in prostate cancer cells is regulated by Sp1 transcription factor and C-EBP alpha PMID: 21549806
    3. Role for 17-beta-HSDXI in androgen metabolism during steroidogenesis. PMID: 12697717
    4. Mutation analyses suggest that the PAT-like motif in 17betaHSD11 will not be functionally similar to the canonical PAT motif. PMID: 18804447
    5. Increased Pan1b is associated with prostate cancer of seminal vesicle invasion. PMID: 19469652

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  • 亞細胞定位：
    Endoplasmic reticulum. Lipid droplet.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
  • 組織特異性：
    Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in
  • 數(shù)據(jù)庫鏈接：

    HGNC: 22960

    OMIM: 612831

    KEGG: hsa:51170

    STRING: 9606.ENSP00000351035

    UniGene: Hs.594923