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  4. IDH3B Antibody

IDH3B Antibody

  • 中文名稱：
    IDH3B兔多克隆抗體
  • 貨號：
    CSB-PA114986
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA114986(IDH3B Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HepG2 cells, mouse kidney tissue, lovo cells, mouse eyes tissue, hela cells, Primary antibody: CSB-PA114986(IDH3B Antibody) at dilution 1/233.3, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    IDH3B
  • 別名：
    FLJ11043 antibody; H-IDHB antibody; Idh3B antibody; IDH3B_HUMAN antibody; Isocitrate dehydrogenase [NAD] subunit beta antibody; Isocitrate dehydrogenase [NAD] subunit beta; mitochondrial antibody; isocitrate dehydrogenase 3; beta subunit antibody; Isocitric dehydrogenase antibody; Isocitric dehydrogenase subunit beta antibody; MGC903 antibody; mitochondrial antibody; NAD(+)-specific ICDH antibody; NAD(+)-specific ICDH subunit beta antibody; NAD+-specific isocitrate dehydrogenase b subunit antibody; NAD+-specific isocitrate dehydrogenase beta antibody; OTTHUMP00000030023 antibody; OTTHUMP00000030024 antibody; RP46 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human IDH3B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
  • 基因功能參考文獻：
    1. Human NAD-dependent isocitrate dehydrogenase (IDH) is a heterotetrameric mitochondrial enzyme with 2alpha:1beta:1gamma subunit ratio subunits shich share 40-52% identity in amino acid sequence. PMID: 20435888
    2. IDPm activity appears to be modulated through enzymatic glutathionylation and deglutathionylation during oxidative stress PMID: 15653693
    3. Asp192 is needed for optimal affinity of IDH beta subunit for nicotinamide-adenine dinucleotide (NAD) substrate, but is not critical for catalysis. PMID: 17432878
    4. Homozygous for loss-of-function mutations in IDH3B is associated with retinitis pigmentosa. PMID: 18806796
    5. The point mutations of isocitrate dehydrogenase are essentially unique to gliomas. PMID: 19498431

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  • 相關疾?。?/div>
    Retinitis pigmentosa 46 (RP46)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Isocitrate and isopropylmalate dehydrogenases family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5385

    OMIM: 604526

    KEGG: hsa:3420

    STRING: 9606.ENSP00000370223

    UniGene: Hs.436405