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  4. INSRR Antibody, Biotin conjugated

INSRR Antibody, Biotin conjugated

  • 中文名稱：
    INSRR兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA011755LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) INSRR Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    INSRR antibody; INSRR_HUMAN antibody; Insulin Receptor R antibody; Insulin receptor related receptor precursor antibody; Insulin receptor-related protein alpha chain antibody; Insulin receptor-related protein beta chain antibody; insulin receptor-related receptor antibody; IR R antibody; IR related receptor antibody; IR-related receptor antibody; IRR antibody; Sir r antibody; Sirr antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Insulin receptor-related protein (747-921AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Antigen Affinity purified & Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
  • 基因功能參考文獻：
    1. the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain. PMID: 29156593
    2. IRR activation involves two separate centers of pH-dependent rearrangements that act synergistically to induce a major conformational change in the IRR molecule, resulting in internal kinase domains rapprochement and autophosphorylation. PMID: 25597417
    3. IRR activation is not based on a single residue deprotonation in the IRR ectodomain but rather involves synergistic conformational changes at multiple points. PMID: 24121506
    4. Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. (Review) PMID: 23220417
    5. Analysis of structural determinants of alkali sensor IRR positive cooperativity. PMID: 23824460
    6. IRR mRNA expression was found in 25 (51%) neuroblastomas and correlated with stages 1, 2, 3, and 4S disease and with age. PMID: 14654552
    7. Phosphotyrosine detection revealed a lack in the constitutive activation of the IRR described for analogous constructs of the two other members of the family PMID: 15629149
    8. The IRR gene is expressed in the same ovarian compartment, IRR mRNA content increases strikingly in these cells in the afternoon of the first proestrus. PMID: 16195402

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6093

    OMIM: 147671

    KEGG: hsa:3645

    STRING: 9606.ENSP00000357178

    UniGene: Hs.248138