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IRX1 Antibody

  • 中文名稱：
    IRX1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA060139
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    IRX1
  • 別名：
    IRX1 antibody; IRXA1 antibody; Iroquois-class homeodomain protein IRX-1 antibody; Homeodomain protein IRXA1 antibody; Iroquois homeobox protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human IRX1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Multiple evidences suggested that PRMT5 repressed transcription of tumor suppressor IRX1 via recruitment of DNMT3A on promoter. PMID: 29802960
    2. A total of three nonsynonymous mutations (p.Gln240Glu, p.Ser298Asn and p.Ala381Glu) of the IRX1 gene were verified in 215 nonsyndromic congenital heart disease patients. PMID: 28358424
    3. this is the first genome-wide association study of Rheumatoid Factor positivity in Rheumatoid Arthritis. Variation at the IRX1 locus on chromosome 5p15.3 is associated with the presence of Rheumatoid Factor. Our findings indicate that IRX1 and HLA-DRB1 are the strongest genetic factors for Rheumatoid Factor production in Rheumatoid Arthritis. PMID: 26815016
    4. In osteosarcoma cells and lines, IRX1 overexpression was associated with hypomethylation of its own promoter. Experimental modulation in cell lines altered migration, invasion, and resistance to anoikis in vitro, and influenced lung metastasis in mice. PMID: 25822025
    5. Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 genes may play an important role in a pathogenic effect of TGF-beta on RASFs. PMID: 23456299
    6. Helicobacter pylori infection contributes to IRX1 promoter methylation in gastric mucosa. PMID: 21649733
    7. enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion. PMID: 21602894
    8. IRX1 could potentially serve as a biomarker for gastric cancer. PMID: 20440264
    9. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
    10. Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma. PMID: 20440264
    11. Frequent methylation of IRX1 gene is associated with head and neck squamous cell carcinoma PMID: 18559491

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14358

    OMIM: 606197

    KEGG: hsa:79192

    STRING: 9606.ENSP00000305244

    UniGene: Hs.424156