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  4. IRX4 Antibody, HRP conjugated

IRX4 Antibody, HRP conjugated

  • 中文名稱：
    IRX4兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA011836LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) IRX4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    IRX4
  • 別名：
    Homeodomain protein IRXA3 antibody; Iroquois homeobox protein 4 antibody; Iroquois-class homeodomain protein IRX-4 antibody; Iroquoisclass homeodomain protein IRX4 antibody; Irx4 antibody; IRX4_HUMAN antibody; IRXA3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Iroquois-class homeodomain protein IRX-4 protein (287-363AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Likely to be an important mediator of ventricular differentiation during cardiac development.
  • 基因功能參考文獻：
    1. We independently validated IRX4 as a potential prostate cancer risk gene through cis-expression quantitative trait loci analysis of prostate cancer risk variants. PMID: 24022300
    2. the prostate cancer (PC)-susceptibility locus represented by rs12653946 at 5p15 is likely to regulate IRX4 expression in prostate which could suppress PC growth by interacting with the VDR pathway, conferring to PC susceptibility PMID: 22323358
    3. IRX4 had a potential causative impact on the development of congenital heart disease, particularly ventricular septal defect. PMID: 21544582
    4. Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke. PMID: 21779381
    5. Polymorphism A381>G of the Irx4 gene may have a modifier effect on septal thickness, resulting in increased corrected QT dispersion and higher outflow gradients. PMID: 18497553

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 組織特異性：
    Predominantly expressed in cardiac ventricles.
  • 數據庫鏈接：

    HGNC: 6129

    OMIM: 606199

    KEGG: hsa:50805

    STRING: 9606.ENSP00000231357

    UniGene: Hs.196927