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  4. IZUMO1 Antibody

IZUMO1 Antibody

  • 中文名稱：
    IZUMO1兔多克隆抗體
  • 貨號：
    CSB-PA812903LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA812903LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA812903LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) IZUMO1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    IZUMO1
  • 別名：
    FLJ61440 antibody; IZUM1_HUMAN antibody; IZUMO antibody; Izumo sperm egg fusion 1 antibody; Izumo sperm-egg fusion protein 1 antibody; Izumo1 antibody; MGC34799 antibody; OBF antibody; Oocyte binding/fusion factor antibody; Sperm specific protein izumo antibody; Sperm-specific protein izumo antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Izumo sperm-egg fusion protein 1 protein (22-292AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，IZUMO1 Antibody (CSB-PA812903LA01HU)，的標(biāo)記方式是Non-conjugated。對于IZUMO1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA812903LB01HU IZUMO1 Antibody, HRP conjugated ELISA
    FITC CSB-PA812903LC01HU IZUMO1 Antibody, FITC conjugated
    Biotin CSB-PA812903LD01HU IZUMO1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
  • 基因功能參考文獻(xiàn)：
    1. crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction PMID: 27309808
    2. crystal structures of human IZUMO1 and JUNO in unbound and bound conformations PMID: 27309818
    3. these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein. PMID: 23279005
    4. human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs [Izumo] PMID: 15759005
    5. We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions. PMID: 18082733
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 18082733

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Izumo family
  • 組織特異性：
    Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28539

    OMIM: 609278

    KEGG: hsa:284359

    STRING: 9606.ENSP00000327786

    UniGene: Hs.400688