KCMF1 Antibody

說明書

中文名稱：

KCMF1兔多克隆抗體
貨號：

CSB-PA873718LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA873718LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA873718LA01HU diluted at 1:500 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KCMF1 Polyclonal antibody
Uniprot No.：

Q9P0J7
基因名：

KCMF1
別名：

KCMF1 antibody; FIGC antibody; ZZZ1 antibody; E3 ubiquitin-protein ligase KCMF1 antibody; EC 2.3.2.27 antibody; FGF-induced in gastric cancer antibody; Potassium channel modulatory factor antibody; PCMF antibody; RING-type E3 ubiquitin transferase KCMF1 antibody; ZZ-type zinc finger-containing protein 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase KCMF1 protein (98-226AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，KCMF1 Antibody (CSB-PA873718LA01HU)，的標記方式是Non-conjugated。對于KCMF1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA873718LB01HU	KCMF1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA873718LC01HU	KCMF1 Antibody, FITC conjugated
Biotin	CSB-PA873718LD01HU	KCMF1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
基因功能參考文獻：
1. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. PMID: 25582440
2. Data indicate that expressions of miR-210 and potassium channel modulatory factor 1 (KCMF1) exhibited an inverse correlation in placentas from patients with severe preeclampsia. PMID: 24980667
3. Data indicate that FIGC upregulation in response to basic fibroblast growth factor in gastric cancer might be implicated in carcinogenesis through dysregulation of growth modulator. PMID: 15581609
4. Suppression of KCMF1 by constitutive high CD99 expression levels contribute to the malignant properties of Ewing's sarcoma by promoting growth and migration of tumor cells PMID: 16314831
蛋白家族：

KCMF1 family
組織特異性：

Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at low levels in the thymus, prostate, testis, colon, heart, brain, placenta and liver.
數(shù)據(jù)庫鏈接：

HGNC: 20589

OMIM: 614719

KEGG: hsa:56888

STRING: 9606.ENSP00000386738

UniGene: Hs.654968