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KCNRG Antibody, FITC conjugated

  • 中文名稱(chēng)：
    KCNRG兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA847638LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) KCNRG Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KCNRG
  • 別名：
    KCNRG antibody; CLLD4Potassium channel regulatory protein antibody; Potassium channel regulator antibody; Protein CLLD4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Potassium channel regulatory protein (1-229AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
  • 基因功能參考文獻(xiàn)：
    1. The haploinsufficiency of KCNRG might be relevant to the progression of chronic lymphocytic leukemia (CLL)and multiple myeloma(MM) at least in a subset of patients. PMID: 20237900
    2. KCNRG is an ER-associated protein, which is proposed to regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes. PMID: 19968958
    3. the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3; is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene PMID: 12650944
    4. Results suggest that genetic alterations and the expression of KCNRG might play an important role in the development and/or progression of a subset of hepatocellular carcinoma. PMID: 16819283
    5. Autoantibodies to KCNRG were present in 7 of the 8 patients with respiratory symptoms in autoimmune polyendocrine syndrome type 1 PMID: 19251657
    6. KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. PMID: 12650944

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum.
  • 組織特異性：
    Ubiquitous in normal tissues and expressed in some tumor tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18893

    OMIM: 607947

    KEGG: hsa:283518

    STRING: 9606.ENSP00000324191

    UniGene: Hs.660161