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KDM4D Antibody

  • 中文名稱：
    KDM4D兔多克隆抗體
  • 貨號：
    CSB-PA718355LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA718355LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA718355LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KDM4D Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KDM4D
  • 別名：
    JHD3D antibody; JHDM3D antibody; JmjC domain-containing histone demethylation protein 3D antibody; Jumonji domain-containing protein 2D antibody; Kdm4d antibody; KDM4D_HUMAN antibody; Lysine-specific demethylase 4D antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Lysine-specific demethylase 4D protein (337-499AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，KDM4D Antibody (CSB-PA718355LA01HU)，的標記方式是Non-conjugated。對于KDM4D Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA718355LB01HU KDM4D Antibody, HRP conjugated ELISA
    FITC CSB-PA718355LC01HU KDM4D Antibody, FITC conjugated
    Biotin CSB-PA718355LD01HU KDM4D Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
  • 基因功能參考文獻：
    1. A high nuclear expression of KDM4D in samples of pancreatic resection margins significantly and independently predicted an earlier recurrence and could thus be used in the assessment of risk of relapse in clinical practice. PMID: 29599352
    2. The results demonstrate a novel mechanism by which Kdm4d regulates DNA replication by reducing the H3K9me3 level to facilitate formation of preinitiation complex. PMID: 27679476
    3. KDM4B and KDM4D expression may associate with an aggressive subtype of classical Hodgkin lymphoma and be linked with radioresistance PMID: 27630312
    4. KDM4D-RNA interaction is required for KDM4D accumulation at DNA breakage sites PMID: 25714495
    5. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. PMID: 24550317
    6. The molecular basis for JMJD2 site specificity revealed by X-ray crystallography. PMID: 23219879
    7. Results demonstrate that JMJD2D can stimulate cell proliferation and survival, suggesting that its inhibition may be helpful in the fight against cancer PMID: 22514644
    8. identified two related histone demethylases, JMJD2A and JMJD2D PMID: 17555712

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM3 histone demethylase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25498

    OMIM: 609766

    KEGG: hsa:55693

    STRING: 9606.ENSP00000334181

    UniGene: Hs.503598