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  4. KIF1BP Antibody, Biotin conjugated

KIF1BP Antibody, Biotin conjugated

  • 中文名稱：
    KIF1BP兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA836204LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) KIF1BP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KIF1BP
  • 別名：
    Hypothetical protein LOC26128 antibody; KBP antibody; KBP_HUMAN antibody; KIAA1279 antibody; KIF1-binding protein antibody; TTC20 antibody; Uncharacterized protein KIAA1279 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human KIF1-binding protein (24-204AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
  • 基因功能參考文獻：
    1. Both Kif15 and KBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length. PMID: 28445502
    2. Data suggest that KBP functions as a kinesin inhibitor that modulates MT-based cargo motility and depolymerizing activity of a subset of kinesin motors. We propose that misregulation of KBP-controlled kinesin motors may represent the underlying molecular mechanism that contributes to the neuropathological defects observed in Goldberg-Shprintzen syndrome patients. PMID: 26948876
    3. A report on fetal cases with a homozygous mutation in KBP gene in a consanguineous Pakistani family with isolated polymicrogyria. PMID: 24072599
    4. KBP-cytoskeleton interactions is involved in neuronal development in Goldberg-Shprintzen syndrome. PMID: 23427148
  • 相關(guān)疾?。?/div>
    Goldberg-Shprintzen syndrome (GOSHS)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    KIF1-binding protein family
  • 組織特異性：
    Highly expressed in heart, brain, ovary, testis, spinal cord and all specific brain regions examined. Moderate expressed at intermediate level in all other adult tissues examined, as well as in fetal liver and brain. Not expressed in blood leukocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23419

    OMIM: 609367

    KEGG: hsa:26128

    STRING: 9606.ENSP00000354848

    UniGene: Hs.279580