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  4. KIN Antibody

KIN Antibody

  • 中文名稱：
    KIN兔多克隆抗體
  • 貨號：
    CSB-PA012351GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    KIN
  • 別名：
    KIN antibody; BTCD antibody; KIN17DNA/RNA-binding protein KIN17 antibody; Binding to curved DNA antibody; KIN antibody; antigenic determinant of recA protein homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human KIN
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro.
  • 基因功能參考文獻(xiàn)：
    1. Findings demonstrate that kin17 is closely related to the cell proliferation and invasion of cervical cancer. PMID: 28346239
    2. overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype. PMID: 24755081
    3. Trimethylated at Lys-135 by METTL22 PMID: 23349634
    4. up-regulation of kin17 is strongly associated with cellular proliferation, DNA replication, DNA damage response and breast cancer development PMID: 21980430
    5. ionizing radiation triggers chromatin complex formation in human cells PMID: 11880372
    6. The overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication. PMID: 12359749
    7. results indicate the presence of functional XPA and XPC proteins is essential for the up-regulation of the KIN17 gene after UVC irradiation; also show that the integrity of global genome repair is required to trigger KIN17 gene expression PMID: 12525703
    8. KIN17 protein may be a component of the DNA replication machinery that participates in the cellular response to unrepaired DSBs, and an impaired KIN17 pathway leads to an increased sensitivity to ionizing radiation. PMID: 12751957
    9. A chromatin-associated protein conserved during evolution and overproduced in certain human tumor cell lines, which is involved in DNA replication. PMID: 12754299
    10. Kin17 protein strongly associates in vivo with DNA fragments containing replication origins in both human HeLa and monkey CV-1 cells. PMID: 15831485
    11. C-terminal domain of human KIN17 has a basic pI, heavy-atom derivatives were obtained by soaking crystals with negatively charged ions such as tungstate & iodine. Replacement of LiCl by KI in cryosolution allowed determination of phases from iodide ions. PMID: 16511313
    12. Analysis of KIN17 structure complexed with tungstate shows structural variability within the domain PMID: 17045609
    13. Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix. PMID: 18029424

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    KIN17 family
  • 組織特異性：
    Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6327

    OMIM: 601720

    KEGG: hsa:22944

    STRING: 9606.ENSP00000368881

    UniGene: Hs.397918