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  4. LEFTY1 Antibody, FITC conjugated

LEFTY1 Antibody, FITC conjugated

  • 中文名稱：
    LEFTY1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA012857LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LEFTY1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    LEFTY1 antibody; LEFTB antibody; LEFTYB antibody; UNQ278/PRO317Left-right determination factor 1 antibody; Left-right determination factor B antibody; Protein lefty-1 antibody; Protein lefty-B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Left-right determination factor 1 protein (223-260AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
  • 基因功能參考文獻(xiàn)：
    1. functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
    2. Studied genes involved in TGF-beta/BMP signaling pathway including chorionic villi LEFTY1 expression levels in association with miscarriage. PMID: 30027725
    3. Lefty1 could regulates the cell cycle via modulating the expressions of P57 and cyclin D1 and then inhibit the decidualization in vitro. PMID: 25339094
    4. The mRNA levels of LSD1 and beta-catenin are inversely correlated with the levels of Lefty1 in pancreas and breast tumors. PMID: 23592333
    5. Reprogrammed cancer cells share the mechanism for expression of Lefty with induced pluripotent cancer cells (iPS), thus contributing to the cancerous transformation of iPS cells. PMID: 23407711
    6. Data suggest that Lefty is a novel TGF-beta target molecule that mediates growth inhibition of pancreatic cancer cells. PMID: 22441145
    7. Findings suggest that Lefty1 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
    8. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
    9. The expression of Nodal in normal and malignant endometrial cells that lack Lefty strongly supports an important role for this embryonic morphogen in the tissue remodelling events that occur across the menstrual cycle and in tumourogenesis. PMID: 19874624
    10. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
    11. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6552

    OMIM: 603037

    KEGG: hsa:10637

    STRING: 9606.ENSP00000272134

    UniGene: Hs.656214