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LIM2 Antibody

  • 中文名稱：
    LIM2兔多克隆抗體
  • 貨號：
    CSB-PA012946ESR1HU
  • 規(guī)格：
    ￥440
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LIM2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LIM2
  • 別名：
    LIM2; Lens fiber membrane intrinsic protein; MP18; MP19; MP20
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Lens fiber membrane intrinsic protein (25-110AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
  • 基因功能參考文獻(xiàn)：
    1. A novel missense mutation in LIM2 is responsible for autosomal recessive congenital cataracts. PMID: 27814360
    2. we report the absence of mutations in all studied genes in four families with phenotypes associating cataract, mental retardation and microcephaly. PMID: 22103961
    3. The genetic mutation in GJA3, GJA8, and LIM2 may slightly contribute to the development of age-related cataracts. PMID: 21386927
    4. Since the LIM2 gene promoter does not contain a classic TATA box, the Hsu element may serve as the site for binding the RNA polymerase complex. PMID: 15968979
    5. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family PMID: 11917274
    6. This study shows the involvement of LIM2 in human congenital cataract. PMID: 18596884

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  • 相關(guān)疾?。?/div>
    Cataract, multiple types 19 (CTRCT19)
  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PMP-22/EMP/MP20 family
  • 組織特異性：
    Eye lens specific.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6610

    OMIM: 154045

    KEGG: hsa:3982

    UniGene: Hs.162754