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LRIG3 Antibody

  • 中文名稱：
    LRIG3兔多克隆抗體
  • 貨號：
    CSB-PA751017LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of U251 cells with CSB-PA751017LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LRIG3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LRIG3
  • 別名：
    Leucine-rich repeats and immunoglobulin-like domains protein 3 antibody; Leucine-rich repeats- and immunoglobulin-like domains- containing protein 3 antibody; LIG-3 antibody; LIG3 antibody; LRIG1-3 antibody; Lrig3 antibody; LRIG3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Leucine-rich repeats and immunoglobulin-like domains protein 3 protein (835-985AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，LRIG3 Antibody (CSB-PA751017LA01HU)，的標(biāo)記方式是Non-conjugated。對于LRIG3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA751017LB01HU LRIG3 Antibody, HRP conjugated ELISA
    FITC CSB-PA751017LC01HU LRIG3 Antibody, FITC conjugated
    Biotin CSB-PA751017LD01HU LRIG3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.
  • 基因功能參考文獻(xiàn)：
    1. Role of LRIG3 in cancer [review] PMID: 27628597
    2. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
    3. LRIG3 functions as a tumor suppressor by attenuating EGFR signaling pathway. PMID: 25708990
    4. LRIG3 plays an important role in Hela229 cell proliferation, apoptosis, and invasiveness. PMID: 26390694
    5. The results on expression of other tumor markers suggest that LRIG3 is influenced by or influences a pattern of tumor markers in cancer and precancerous cells. PMID: 24998916
    6. In conclusion, the over-expression of LRIG3 could influence the cell cycle and invasion, inhibit proliferation and induce apoptosis in the three bladder cancer cell lines. PMID: 23392718
    7. Data indicate that Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptors ERBB2, ERBB3 and ERBB4 stability. PMID: 23723069
    8. High LRIG3 expression is associated with cervical adenocarcinoma progression. PMID: 23165628
    9. Silencing LRIG3 inhibited the proliferation and promoted the apoptosis of bladder cancer T24 cells. PMID: 21505989
    10. siRNA targeting LRIG3 gene shows a dramatic inhibitory effect on RNA transcription and protein expression, then promotes the proliferation and suppresses apoptosis of GL15 cells. PMID: 19224171
    11. These results indicate that expression and sub-cellular localization of LRIG1-3 might be of importance in the pathogenesis and prognosis of astrocytic tumors. PMID: 16532360
    12. Down-regulation of LRIG3 in HP75 pituitary adenoma is reported. PMID: 17393120
    13. LRIG proteins may have a role in epidermal homeostasis and psoriasis PMID: 18037903
    14. LRIG3 may be involved in the regulation of EGF receptor signaling, and serve as a tumor suppressor gene in the pathogenesis of glioma. PMID: 19200647
    15. the expression of LRIG1-3 was evaluated in 51 human ependymomas and was found to be more highly expressed in supratentorial than in infratentorial ependymomas PMID: 19216216
    16. Down-regulating LRIG3 gene expression can improve the proliferation of glioma GL15 cells. PMID: 19448407

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30991

    OMIM: 608870

    KEGG: hsa:121227

    STRING: 9606.ENSP00000326759

    UniGene: Hs.253736