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  4. LYL1 Antibody

LYL1 Antibody

  • 中文名稱：
    LYL1兔多克隆抗體
  • 貨號：
    CSB-PA284084
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Lyl-1 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LYL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LYL1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human Lyl-1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. Despite not being identified as an independent prognostic factor in UCEC, LYL1 gene amplification is associated with other poor prognostic factors and correlated with upregulation of cancer-related pathways. PMID: 29716549
    2. In t(8;21) leukemia cells, LYL1 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis. PMID: 23812588
    3. LYL1 degradation is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PMID: 20844761
    4. LYL1 activity is required for the maturation of newly formed blood vessels in adulthood. PMID: 20418284
    5. Over-expression of LYL1 is highly associated with AML as well as ALL. PMID: 19176012
    6. Multiple mechanisms which activate LYL1 in leukemic cells, including structural genomic alterations, namely microdeletion or amplification, together with the involvement of prominent oncogenic transcription factors. PMID: 19608273
    7. LYL1 may play a role in early hematopoiesis and may be a potential oncogenic factor in AML PMID: 16094422
    8. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. PMID: 18160048

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  • 相關(guān)疾?。?/div>
    A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.
  • 亞細胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6734

    OMIM: 151440

    KEGG: hsa:4066

    STRING: 9606.ENSP00000264824

    UniGene: Hs.46446