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MAPK4 Antibody

  • 中文名稱：
    MAPK4兔多克隆抗體
  • 貨號：
    CSB-PA013457ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: MAPK4 ntibody at 6μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: 293T whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 66 kDa
      Observed band size: 66 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA013457ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA013457ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MAPK4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ERK-4 antibody; ERK3 antibody; Erk3 related antibody; ERK4 antibody; Extracellular signal regulated kinase 4 antibody; Extracellular signal-regulated kinase 4 antibody; MAP kinase 4 antibody; MAP kinase isoform p63 antibody; MAPK 4 antibody; MAPK4 antibody; Mitogen activated protein kinase 4 antibody; Mitogen-activated protein kinase 4 antibody; MK04_HUMAN antibody; p63 MAPK antibody; p63-MAPK antibody; p63MAPK antibody; PRKM4 antibody; Protein kinase; mitogen-activated; 4 antibody; Protein-tyrosine kinase ERK3-related antibody; RMNK2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Mitogen-activated protein kinase 4 protein (348-587AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.
  • 基因功能參考文獻：
    1. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. PMID: 21177870
    2. Data defined a novel MK5 interaction motif (FRIEDE) within both ERK4 and ERK3 that is essential for binding to the C-terminal region of MK5. PMID: 19473979
    3. Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3. PMID: 16973613
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
  • 組織特異性：
    High expression in heart and brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6878

    OMIM: 176949

    KEGG: hsa:5596

    STRING: 9606.ENSP00000383234

    UniGene: Hs.433728