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ME2 Antibody, HRP conjugated

  • 中文名稱：
    ME2兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA013633HB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ME2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Malate dehydrogenase antibody; Malic enzyme 2 antibody; Malic enzyme 2 mitochondrial antibody; Malic enzyme 2 NAD(+) dependent mitochondrial antibody; Malic enzyme mitochondrial antibody; Malic enzyme NAD(+) dependent mitochondrial antibody; MAOM_HUMAN antibody; ME 2 antibody; ME2 antibody; mitochondrial antibody; NAD dependent malic enzyme mitochondrial antibody; NAD ME antibody; NAD-dependent malic enzyme antibody; NAD-ME antibody; ODS1 antibody; Pyruvic malic carboxylase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human NAD-dependent malic enzyme, mitochondrial protein (296-424AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. ME2 was involved in glioblastoma multiforme growth, invasion, migration, Reactive oxygen species and ATP production. PMID: 27166188
    2. deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer PMID: 28099419
    3. Data indicate that malic enzyme 2 knockdown impacts phosphatidylinositol 3-kinases/proto-oncogene protein akt (PI3K/AKT) signaling. PMID: 24957098
    4. ME2 might be an important factor in melanoma progression and a novel biomarker of invasion. PMID: 25202825
    5. Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy. PMID: 23756480
    6. Depletion of malic enzyme 2 induced erythroid differentiation in human erythroleukemia cells. PMID: 20824065
    7. An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype PMID: 15532013
    8. Site directed mutagenesis was used to detrmine which amino acids in the active site of human mitochondrial NAD+-dependent malic enzyme are necessary for the inhibitory effects of ATP. PMID: 16171388
    9. These findings provide a molecular rationale for the role of hS14 in TR-dependent transcriptional activation of the expression of specific genes. PMID: 17418816
    10. Schizophrenic subjects are identified with mitochondrial genes involved in oxidative metabolism as showing consistently decreased expression, including ME2. PMID: 17638511
    11. Single nucleotide polymorphism in ME2 gene is associated with acute lymphoblastic leukemia. PMID: 19066393
    12. ME2 activity in Islets of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties. PMID: 19691144

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  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Malic enzymes family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6984

    OMIM: 154270

    KEGG: hsa:4200

    STRING: 9606.ENSP00000321070

    UniGene: Hs.233119