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  4. MRPL58 Antibody, HRP conjugated

MRPL58 Antibody, HRP conjugated

  • 中文名稱：
    MRPL58兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA613490HB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MRPL58 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MRPL58
  • 別名：
    Digestion substraction 1 antibody; DS-1 antibody; DS1 antibody; Ict1 antibody; ICT1_HUMAN antibody; Immature colon carcinoma transcript 1 antibody; Immature colon carcinoma transcript 1 protein antibody; mitochondrial antibody; Peptidyl-tRNA hydrolase ICT1 antibody; Peptidyl-tRNA hydrolase ICT1, mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Peptidyl-tRNA hydrolase ICT1, mitochondrial protein (30-206AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
  • 基因功能參考文獻(xiàn)：
    1. High ICT1 expression is associated with leukemia. PMID: 29328466
    2. ICT1 overexpression notably predicted poor prognosis of gastric cancer patients. PMID: 28987942
    3. Study demonstrates that ICT1 overexpression correlates with malignant clinical features and poor prognosis of hepatocellular carcinoma (HCC) patients. Functionally, ICT1 promotes proliferation, cell cycle progression and inhibits apoptosis of HCC cells. ICT1 regulates the expressions of CDK1, cyclin B1, Bcl-2 and Bax, and is directly targeted by microRNA-134 (miR-134) in HCC cells. PMID: 29130100
    4. ICT1 may play a crucial role in promoting gastric cancer proliferation in vitro. PMID: 29036264
    5. The results provide direct evidence that localized feedbacks on Fat4-Ds1 complexes can give rise to planar cell polarity. PMID: 28826487
    6. our preliminary study reveals the important role of ICT1 in NSCLC cells that knockdown of ICT1 significantly suppressed cell proliferation, arrested cell cycle though altering expression cell cycle regulators, and promoted cell apoptosis. PMID: 27413166
    7. ICT1 knockdown significantly inhibited cell proliferation and migration, led to G2/M phase cell-cycle arrest, and triggered apoptosis via the intracellular AMPKa, SAPK/JNK, and PARP signaling pathways. PMID: 27411551
    8. ICT1 was significantly upregulated in diffuse large B-cell lymphoma tissues (DLBCL) and correlated with poor survival. Knockdown of ICT1 remarkably induced cell cycle G0/G phase arrest and apoptosis in DLBCL cells. PMID: 28629825
    9. ICT1 knockdown altered the expression of apoptosis- or cell cyclerelated proteins such as Bcl-2, caspase-3, CDK1, CDK2 and cyclin B. PMID: 28290601
    10. ICT1 may be essential for hydrolysis of prematurely terminated peptidyl-tRNA moieties in stalled mitoribosomes. PMID: 20186120

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  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Prokaryotic/mitochondrial release factor family, Mitochondrion-specific ribosomal protein mL62 subfamily
  • 組織特異性：
    Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5359

    OMIM: 603000

    KEGG: hsa:3396

    STRING: 9606.ENSP00000301585

    UniGene: Hs.407955