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MXD4 Antibody

  • 中文名稱：
    MXD4兔多克隆抗體
  • 貨號：
    CSB-PA006661
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MXD4
  • 別名：
    bHLHc12 antibody; Class C basic helix loop helix protein 12 antibody; Class C basic helix-loop-helix protein 12 antibody; MAD 4 antibody; MAD4 antibody; Mad4 homolog antibody; MAD4_HUMAN antibody; Max associated protein 4 antibody; MAX dimerization protein 4 antibody; Max dimerizer 4 antibody; Max interacting transcriptional repressor MAD4 antibody; Max-associated protein 4 antibody; Max-interacting transcriptional repressor MAD4 antibody; MST 149 antibody; MST149 antibody; MSTP 149 antibody; MSTP149 antibody; MXD 4 antibody; MXD4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Mad 4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
  • 基因功能參考文獻：
    1. The E3 ligase activity of c-IAP1 was not required for downregulation of Mad4 expression. PMID: 22895069
    2. regulation by a transcriptional repressor complex that contains Miz-1 and c-Myc PMID: 12418961
    3. Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells. PMID: 15469726
    4. replicative senescence-specific factors may block c-Myc inhibition of Miz-1 activation of hMad4 expression, and the continual presence of hMad4 protein may transcriptionally repress selected c-Myc target genes PMID: 16167342
  • 亞細胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13906

    KEGG: hsa:10608

    STRING: 9606.ENSP00000337889

    UniGene: Hs.655020