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  4. MYL4 Antibody

MYL4 Antibody

  • 中文名稱：
    MYL4兔多克隆抗體
  • 貨號：
    CSB-PA015311GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ALC 1 antibody; ALC1 antibody; AMLC antibody; Atrial/embryonic alkali myosin light chain antibody; embryonic muscle/atrial isoform antibody; GT 1 antibody; GT1 antibody; MLC 1 antibody; MLC1 antibody; MYL 4 antibody; Myl4 antibody; MYL4_HUMAN antibody; Myosin atrial/fetal muscle light chain antibody; Myosin light chain 1 antibody; Myosin light chain 1 embryonic muscle/atrial isoform antibody; Myosin light chain 4 alkali atrial embryonic antibody; Myosin light chain 4 antibody; Myosin light chain alkali GT 1 isoform antibody; Myosin light chain alkali GT-1 isoform antibody; Myosin light polypeptide 4 alkali atrial embryonic antibody; Myosin light polypeptide 4 antibody; PRO1957 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MYL4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Regulatory light chain of myosin. Does not bind calcium.
  • 基因功能參考文獻(xiàn)：
    1. The authors describe in a population approach a loss of function mutation in the myosin gene MYL4 that, in the homozygous state, is completely penetrant for early-onset AF. The finding may provide novel mechanistic insight into the pathophysiology of this complex arrhythmia. PMID: 27742809
    2. a novel, heterozygous p.Glu11Lys mutation in the atrial-specific myosin light chain gene MYL4, caused atrial fibrillation. PMID: 27066836
    3. A recessive frameshift mutation in MYL4 causes early-onset atrial fibrillation. PMID: 25807286
    4. results demonstrate that the expression of hALC-1 could have a beneficial effect on the overloaded hypertrophied heart PMID: 16106982
    5. The (Ala-Pro) rich part of this protein acts as a "spacer arm" responsible for correct positioning of the N-terminal actin binding site. PMID: 9000508
    6. The N-terminus of this protein is an actin binding site. PMID: 9738905
    7. NMR showed involvement of N-terminus and lysines 3 and 4 in interaction with actin. Mutations of these lysines (K3A,K4R,K4A,K4D) resulted in altered actin binding and actin activated MgATPase. Mutation of Ala-1 to val had no effect on binding or kinetics. PMID: 10373429

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  • 相關(guān)疾?。?/div>
    Atrial fibrillation, familial, 18 (ATFB18)
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7585

    OMIM: 160770

    KEGG: hsa:4635

    STRING: 9606.ENSP00000347055

    UniGene: Hs.463300