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MYSM1 Antibody

  • 中文名稱：
    MYSM1兔多克隆抗體
  • 貨號：
    CSB-PA919414
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA919414(MYSM1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MYSM1
  • 別名：
    2A-DUB antibody; 2ADUB antibody; Histone H2A deubiquitinase antibody; Histone H2A deubiquitinase MYSM1 antibody; KIAA1915 antibody; Myb like SWIRM and MPN domains 1 antibody; Myb like, SWIRM and MPN domain containing protein antibody; Myb like, SWIRM and MPN domains 1 antibody; Myb-like antibody; Myb-like, SWIRM and MPN domains 1 antibody; MYSM 1 antibody; mysm1 antibody; MYSM1 Myb-like, SWIRM and MPN domains 1 antibody; MYSM1_HUMAN antibody; RP4-592A1.1 antibody; SWIRM and MPN domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human MYSM1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome.
  • 基因功能參考文獻：
    1. Data indicate a pathway MYSM1/miR-150/FLT3 that inhibits proliferation of B1a cells, which may be involved in the pathogenesis of systemic lupus erythematosus (SLE). PMID: 27590507
    2. this study shows that MYSM1 deficiency is associated with developmental aberrations, progressive bone marrow failure with myelodysplastic features, and increased susceptibility to genotoxic stress PMID: 28115216
    3. data suggested that expression of MYSM1 was associated with the progression of CRC and might be a potential biomarker for clinical prognosis PMID: 28498834
    4. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation PMID: 26220525
    5. the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings PMID: 24288411
    6. The SWIRM structure of human MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM1), is reported. PMID: 17428495
    7. The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported. PMID: 17707232

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Peptidase M67A family, MYSM1 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29401

    OMIM: 612176

    KEGG: hsa:114803

    STRING: 9606.ENSP00000418734

    UniGene: Hs.744921