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NAPRT Antibody

  • 中文名稱：
    NAPRT兔多克隆抗體
  • 貨號(hào)：
    CSB-PA015451EA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, Mouse liver tissue, Mouse kidney tissue
      All lanes: NAPRT antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 58, 61, 57 kDa
      Observed band size: 58 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NAPRT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NAPRT
  • 別名：
    FHA HIT interacting protein antibody; FHA-HIT-interacting protein antibody; FHIP antibody; NAPRT1 antibody; NAPRTase antibody; Nicotinate phosphoribosyltransferase antibody; Nicotinate phosphoribosyltransferase domain containing 1 antibody; Nicotinate phosphoribosyltransferase domain-containing protein 1 antibody; Nicotinic acid phosphoribosyltransferase antibody; PNCB_HUMAN antibody; PP3856 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Nicotinate phosphoribosyltransferase protein (1-310AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，NAPRT Antibody (CSB-PA015451EA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于NAPRT Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA015451EB01HU NAPRT Antibody, HRP conjugated ELISA
    FITC CSB-PA015451EC01HU NAPRT Antibody, FITC conjugated
    Biotin CSB-PA015451ED01HU NAPRT Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
  • 基因功能參考文獻(xiàn)：
    1. No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma PMID: 28860121
    2. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases PMID: 28416276
    3. High NAPRTase expression is associated with neoplasms. PMID: 26675378
    4. Tumor-specific promoter hypermethylation of NAPRT1 inactivates one of two NAD salvage pathways, resulting in synthetic lethality with the coadministration of a NAMPT inhibitor. PMID: 24097869
    5. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner PMID: 22570471
    6. NAPRT expression was varied in lymphomas with 30-50% low expression except for Hodgkin's lymphoma where 85% displayed low expression PMID: 21492230
    7. NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD PMID: 17604275

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  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    NAPRTase family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30450

    OMIM: 611552

    KEGG: hsa:93100

    STRING: 9606.ENSP00000401508

    UniGene: Hs.493164