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NDUFAF4 Antibody

  • 中文名稱:
    NDUFAF4兔多克隆抗體
  • 貨號(hào):
    CSB-PA959809
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA959809(NDUFAF4 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA959809(NDUFAF4 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA959809(NDUFAF4 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    NDUFAF4
  • 別名:
    C6orf66 antibody; Hormone-regulated proliferation-associated protein of 20 kDa antibody; HRPAP20 antibody; HSPC125 antibody; My013 antibody; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 antibody; NDUF4_HUMAN antibody; Ndufaf4 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human NDUFAF4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.
  • 基因功能參考文獻(xiàn):
    1. A homozygous missense NDUFAF4 variant was identified in a complex I-deficient patient with Leigh syndrome. PMID: 28853723
    2. observations suggest that HRPAP20 may be an important regulator of breast tumor cell invasion by a CaM-mediated mechanism that leads to increased MMP-9 secretion PMID: 17001319
    3. HRPAP20 and TIMELESS as promising markers of tamoxifen resistance in women with ER alpha-positive breast tumors. PMID: 17909269
    4. Homozygosity mapping of 5 patients from a consanguineous family with infantile mitochondrial encephalomyopathy resulted in the identification of a missense mutation in a conserved residue of the C6ORF66. PMID: 18179882
    5. Specific lack of complex I was detected in thyroid cancers expressing less than 5% of the amount in surrounding non-cancerous tissue. PMID: 19352385

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  • 相關(guān)疾?。?/div>
    Mitochondrial complex I deficiency (MT-C1D)
  • 亞細(xì)胞定位:
    Mitochondrion. Membrane; Lipid-anchor.
  • 蛋白家族:
    NDUFAF4 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 21034

    OMIM: 252010

    KEGG: hsa:29078

    STRING: 9606.ENSP00000358272

    UniGene: Hs.512144