NFE2L3 Antibody, Biotin conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) NFE2L3 Polyclonal antibody
Uniprot No.：

Q9Y4A8
基因名：

NFE2L3
別名：

NFE2L3 antibody; NRF3 antibody; Nuclear factor erythroid 2-related factor 3 antibody; NF-E2-related factor 3 antibody; NFE2-related factor 3 antibody; Nuclear factor antibody; erythroid derived 2 antibody; like 3 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Nuclear factor erythroid 2-related factor 3 protein (132-260AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Activates erythroid-specific, globin gene expression.
基因功能參考文獻(xiàn)：
1. SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM. PMID: 28554271
2. findings reveal FBW7 and GSK3 as novel regulators of the NFE2L3 transcription factor and a potential mechanism by which FBW7 might regulate detoxification and the cellular response to stress PMID: 26306035
3. 17beta-Estradiol treatment significantly increased but VC or Res decreased Nrf3 mRNA and protein expression levels. PMID: 25130429
4. Nrf3 is a negative regulator of ARE-mediated gene expression of NQO1 PMID: 15385560
5. NRF3 is highly expressed in primary placental cytotrophoblasts PMID: 15388789
6. Nrf3 is an N-glycosylated protein associated with the endoplasmic reticulum PMID: 17976382
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

BZIP family, CNC subfamily
組織特異性：

Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 7783

OMIM: 604135

KEGG: hsa:9603

STRING: 9606.ENSP00000056233

UniGene: Hs.404741