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  4. NFIX Antibody, FITC conjugated

NFIX Antibody, FITC conjugated

  • 中文名稱：
    NFIX兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA617941LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NFIX Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NFIX
  • 別名：
    CCAAT box binding transcription factor antibody; CCAAT-box-binding transcription factor antibody; CTF antibody; NF-I/X antibody; NF1-X antibody; NF1A antibody; NF1X antibody; NFI X antibody; NFI-X antibody; NFI/X antibody; NFIX antibody; NFIX_HUMAN antibody; Nuclear factor 1 X type antibody; Nuclear factor 1 X-type antibody; Nuclear factor 1/X antibody; Nuclear factor I/X antibody; TGGCA binding protein antibody; TGGCA-binding protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Nuclear factor 1 X-type protein (201-440AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
  • 基因功能參考文獻：
    1. Microduplications encompassing NFIX cause intellectual disability, short stature and small head circumference. PMID: 29184170
    2. Compared to noncancerous esophageal mucosa, miR-1290 expression was upregulated, while NFIX mRNA expression was downregulated in ESCC tissues. Data suggest that the dysregulation of miR-1290-NFIX axis may play crucial roles in esophageal carcinogenesis and progression. PMID: 28800311
    3. A novel de novo pathogenic variant in the NFIX gene identified in a case of Marshall-Smith syndrome with precocious puberty and aortic root dilatation. PMID: 28442439
    4. Plasma miR-1914* and -1915 interact with NFIX RNA. PMID: 26695693
    5. Report novel mutations of NFIX gene causing Marshall-Smith syndrome or Sotos-like syndrome. PMID: 26200704
    6. miR-1290 functions as a tumor oncogene in the progression of esophageal squamous cell carcinoma by targeting NFIX PMID: 26653554
    7. NFIX analysis should be considered in patients presenting with overgrowth, macrocephaly and developmental delay including those in whom Sotos syndrome has been considered clinically but are negative for pathogenic NSD1 variants. PMID: 25118028
    8. Deletions in the 3' part of the NFIX gene including a recurrent Alu-mediated deletion of exon 6 and 7 account for previously unexplained cases of Marshall-Smith syndrome. PMID: 24924640
    9. missense mutations in NFIX were able to cause Sotos-like features. PMID: 22301465
    10. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. PMID: 22422452
    11. NFI-X3 and STAT3 control the migration of differentiating astrocytes as well as migration and invasion of glioma cells via regulating YKL-40 expression. PMID: 21953450
    12. NFI-X3 activates GFAP expression, in part, by inducing alterations in the nucleosome architecture that lead to the increased recruitment of RNA polymerase II PMID: 21189253
    13. These findings demonstrate that allelic NFIX mutations trigger distinct phenotypes, depending specifically on their impact on nonsense-mediated mRNA decay. PMID: 20673863
    14. Nuclear factor IA may play a role in astrocytoma biology. PMID: 20150379
    15. NFI-X cooperates with (activator protein 1)AP-1 by an unknown mechanism in astrocytes, which results in the expression of a subset of astrocyte-specific genes. PMID: 16565071
    16. temporal and dose-dependent interference by an AP-1 family member, c-Jun, upon NF-1 proteins binding an NF-1 consensus site derived from JC virus promoter sequence PMID: 16928756
    17. First report of structural alterations of the NFIA gene in hematopoietic diseases (polycythemia vera and chronic myelomonocytic leukemia, type 1). PMID: 18754024
    18. an expression program of NFIs is executed during the differentiation of astrocytes, with NFI-X and -C controlling the expression of astrocytic markers at late stages of differentiation. PMID: 19418463

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  • 相關疾病：
    Sotos syndrome 2 (SOTOS2); Marshall-Smith syndrome (MRSHSS)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    CTF/NF-I family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7788

    OMIM: 164005

    KEGG: hsa:4784

    STRING: 9606.ENSP00000380781

    UniGene: Hs.257970