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NKX2-8 Antibody

  • 中文名稱：
    NKX2-8兔多克隆抗體
  • 貨號：
    CSB-PA015847LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA015847LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA015847LA01HU diluted at 1:300 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) NKX2-8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NKX2-8
  • 別名：
    Homeobox protein NK 2 homolog H antibody; Homeobox protein NK-2 homolog H antibody; Homeobox protein Nkx 2.8 antibody; Homeobox protein Nkx-2.8 antibody; NK 2 homolog 8 antibody; NK 2 homolog H antibody; NK2 homeobox 8 antibody; NK2 transcription factor related; locus 8 antibody; Nkx2 9 antibody; Nkx2-8 antibody; NKX2.8 antibody; NKX28_HUMAN antibody; NKX2G antibody; NKX2H antibody; OTTHUMP00000027959 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein Nkx-2.8 protein (1-160AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，NKX2-8 Antibody (CSB-PA015847LA01HU)，的標記方式是Non-conjugated。對于NKX2-8 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA015847LB01HU NKX2-8 Antibody, HRP conjugated ELISA
    FITC CSB-PA015847LC01HU NKX2-8 Antibody, FITC conjugated
    Biotin CSB-PA015847LD01HU NKX2-8 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. Results show that Nkx2-8 functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC), the downregulation of which contributes to NF-kappaB P65 activation and ESCC angiogenesis. PMID: 23604637
    2. overexpression of Nkx2.8 resulted in downregulation of p-FOXO3a and inhibition of MEK/ERK pathway activity. silencing Nkx2.8 led to upregulation of p-FOXO3a and increase of MEK/ERK pathway activity. PMID: 22223847
    3. Most tumors have low expression of Nkx2-8, and its expression can inhibit growth of some lung cancer cells. PMID: 21148747
    4. A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor. PMID: 12167706
    5. Coactivation of the TTF-1 and NKX2-8 pathways identified a cluster of lung cancer patients with poor survival and were shown to exhibit resistance to cisplatin PMID: 19279207

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    NK-2 homeobox family
  • 數(shù)據庫鏈接：

    HGNC: 16364

    OMIM: 603245

    KEGG: hsa:26257

    STRING: 9606.ENSP00000258829

    UniGene: Hs.234763