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NOXA1 Antibody, FITC conjugated

  • 中文名稱：
    NOXA1兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA015963LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NOXA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NOXA1
  • 別名：
    Antigen NY CO 31 antibody; Antigen NY-CO-31 antibody; FLJ25475 antibody; Inhibitory NADPH oxidase activator 1 antibody; MGC131800 antibody; NADPH oxidase activator 1 antibody; NCF2 like protein antibody; NCF2-like protein antibody; NOX activator 1 antibody; NOXA 1 antibody; Noxa1 antibody; NOXA1_HUMAN antibody; NY CO 31 antibody; p51 nox antibody; p51-nox antibody; p51NOX antibody; P67phox like factor antibody; P67phox-like factor antibody; SDCCAG31 antibody; Serologically defined colon cancer antigen 31 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human NADPH oxidase activator 1 protein (150-313AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
  • 基因功能參考文獻(xiàn)：
    1. Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region. PMID: 28625920
    2. A NOXA1 peptide blocked NOXA1-Nox1 binding. The finding identifies a NOXA1-activating domain and an isoform-specific Nox1 inhibitor. PMID: 24187133
    3. Phosphorylation of Thr341 allows Noxo1 to sufficiently interact with Noxa1, an interaction that participates in Nox1 activation PMID: 23957209
    4. Noxa1 has quite different kinetic properties from p67(phox) and suggest that Noxa1 may function as a moderate activator of Nox2. PMID: 22244833
    5. Tks4 and Tks5 directly bind to NoxA1. The integrity of the N-terminal PRR of NoxA1 is essential for this direct interaction with the Tks proteins. PMID: 20609497
    6. The Nox1-dependent generation of reactive oxygen species is dependent on Src phosphorylation of NoxA1 and Tks4. Blockage of phosphorylation of NoxA1 and Tks4 decreases Nox1-dependent ROS generation and blocks SrcYF-induced invadopodia formation. PMID: 20943948
    7. The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented. PMID: 20454568
    8. these results demonstrate that phosphorylation of NoxA1 is a part of the feedback mechanism that functions through activation of Rac with a net outcome of negative modulation of Nox1 activity. PMID: 20230789
    9. NoxA1 is the functional homolog of p67phox in vascular smooth muscle cells (VSMC) that regulates redox signaling and VSMC phenotype. PMID: 20083677
    10. These studies demonstrate that, in reconstituted NOX1/NOXO1/NOXA1 systems, the NOXA1 SH3 domain is not required for function but, when present, can critically modulate the activity of the enzyme system. PMID: 17602954
    11. PKA-phosphorylated NoxA1 is a new binding partner of 14-3-3 protein; this forms the basis of a novel mechanism regulating the formation of ROS by Nox1 and, potentially, other NoxA1-regulated Nox family members PMID: 17913709
    12. Essential role of NOXA1 in generation of reacgtive oxygen species induced by oxidized low density lipoprotein in endothelial cells is reported. PMID: 18568954
    13. a novel, inhibitory function for Noxa1 in Duox1 regulation. PMID: 18606821

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
  • 蛋白家族：
    NCF2/NOXA1 family
  • 組織特異性：
    Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10668

    OMIM: 611255

    KEGG: hsa:10811

    STRING: 9606.ENSP00000342848

    UniGene: Hs.495554