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NPC2 Antibody, FITC conjugated

Rare Species
  • 中文名稱：
    NPC2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA634688LC01DO
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Dog NPC2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    NPC2 antibody; NPC intracellular cholesterol transporter 2 antibody; Epididymal secretory protein E1 antibody; cE1 antibody; Niemann Pick type C2 protein homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Dog
  • 免疫原：
    Recombinant Dog NPC intracellular cholesterol transporter 2 protein (22-149AA)
  • 免疫原種屬：
    Dog
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
  • 亞細(xì)胞定位：
    Secreted. Endoplasmic reticulum. Lysosome.
  • 蛋白家族：
    NPC2 family
  • 組織特異性：
    Epididymis. High levels are found in the caput and corpus regions. Weaker levels in the distal cauda and in the efferent ducts.
  • 數(shù)據(jù)庫(kù)鏈接：