NSMAF Antibody

中文名稱：

NSMAF兔多克隆抗體
貨號(hào)：

CSB-PA856416LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA856416LA01HU diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA856416LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) NSMAF Polyclonal antibody
Uniprot No.：

Q92636
基因名：

NSMAF
別名：

NSMAF antibody; FANProtein FAN antibody; Factor associated with neutral sphingomyelinase activation antibody; Factor associated with N-SMase activation antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Protein FAN protein (1-233AA )
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，NSMAF Antibody (CSB-PA856416LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于NSMAF Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA856416LB01HU	NSMAF Antibody, HRP conjugated	ELISA
FITC	CSB-PA856416LC01HU	NSMAF Antibody, FITC conjugated
Biotin	CSB-PA856416LD01HU	NSMAF Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.
基因功能參考文獻(xiàn)：
1. these data identify a novel caspase-2-interacting factor, FAN, and expand the role for the enzyme in seemingly non-apoptotic cellular mechanisms. PMID: 29621545
2. The rs1050504 C > T genotype was observed to be significantly associated with an increased risk for developing pulmonary tuberculosis. PMID: 29115933
3. The interaction of FAN with receptor for activated C-kinase 1 (RACK1) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN. PMID: 12391233
4. sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase PMID: 15653433
5. Regulation of NSMAF by TNF-alpha involves PRKCD in lung epithelial cells. PMID: 18653803
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組織特異性：

Ubiquitous.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 8017

OMIM: 603043

KEGG: hsa:8439

STRING: 9606.ENSP00000411012

UniGene: Hs.372000