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NT5C3A Antibody

  • 中文名稱：
    NT5C3A兔多克隆抗體
  • 貨號：
    CSB-PA291358
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    NT5C3A
  • 別名：
    5NT3A_HUMAN antibody; cN III antibody; cN-III antibody; cNIII antibody; Cytosolic 5' nucleotidase 3 antibody; Cytosolic 5' nucleotidase III antibody; Cytosolic 5''-nucleotidase 3 antibody; Cytosolic 5''-nucleotidase 3A antibody; Cytosolic 5''-nucleotidase III antibody; NT5C3 antibody; Nt5c3a antibody; p36 antibody; P5''N-1 antibody; P5'N 1 antibody; P5'N1 antibody; P5N 1 antibody; P5N-1 antibody; P5N1 antibody; PN I antibody; PN-I antibody; PNI antibody; PSN1 antibody; Pyrimidine 5' nucleotidase 1 antibody; Pyrimidine 5''-nucleotidase 1 antibody; UMPH antibody; UMPH1 antibody; Uridine 5' monophosphate hydrolase 1 antibody; Uridine 5''-monophosphate hydrolase 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human NT5C3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.
  • 基因功能參考文獻(xiàn)：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that NT5C3A is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. reduced expression of transketolase in pyrimidine 5'-nucleotidase deficient patients PMID: 27381654
    3. Pyrimidine-5'-nucleotidase Campinas is a new mutation (p.R56G) in the NT5C3 gene associated with pyrimidine-5'-nucleotidase type I deficiency. PMID: 25153905
    4. Results show that NT5C3 expression levels were significantly increased in patients with risk allele homozygote. PMID: 25000516
    5. New missense homozygous mutation (Q270Ter) in the pyrimidine 5' nucleotidase type I-related gene in two Indian families with hereditary non-spherocytic hemolytic anemia. PMID: 23139015
    6. All investigated mutant proteins display impaired catalytic properties and/or reduced thermostability, providing a rationale for the pathological effects of the mutations. PMID: 15604219
    7. These data highlight hUMP1/POMP role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system. PMID: 17349762
    8. 3 newly described missense mutations (c.187T>C, c.469G>C & c.740T>C) identified in patients with hemolytic anemia were characterized at protein level; the enzymes were altered in both thermal stability and catalytic efficiency PMID: 18499901
    9. genetic variation in NT5C3 might affect protein function and potentially influence drug response PMID: 19623099

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  • 相關(guān)疾?。?/div>
    P5N deficiency (P5ND)
  • 亞細(xì)胞定位：
    Cytoplasm.; [Isoform 2]: Endoplasmic reticulum.
  • 蛋白家族：
    Pyrimidine 5'-nucleotidase family
  • 組織特異性：
    Isoforms 1, 3 and 4 are expressed in reticulocytes. Isoform 4 is hardly detectable in bone marrow and fetal liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17820

    OMIM: 266120

    KEGG: hsa:51251

    STRING: 9606.ENSP00000242210

    UniGene: Hs.487933