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NUBPL Antibody, Biotin conjugated

  • 中文名稱：
    NUBPL兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA819450LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NUBPL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NUBPL
  • 別名：
    C14orf127 antibody; FLJ12660 antibody; huInd1 antibody; IND1 homolog antibody; Iron-sulfur protein NUBPL antibody; Nubpl antibody; NUBPL_HUMAN antibody; nucleotide binding protein like antibody; Nucleotide-binding protein-like antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Iron-sulfur protein NUBPL protein (39-319AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits.
  • 基因功能參考文獻(xiàn)：
    1. huInd1 binds to the untranslated region of the TEM-1 mRNA at 3' site and thereby reducing the possibility of its endonucleolytic cleavage, resulting in over-expression of TEM-1. PMID: 25240856
    2. Inhibition of ERK suppressed the NUBPL-induced changes in EMT and cell motility. PMID: 28346728
    3. Our data show that NUBPL mutations are associated with a unique, consistent, and recognizable MRI pattern. PMID: 23553477
    4. Mutations in NUBPL is associated with complex I deficiency. PMID: 20818383
    5. These data identify huInd1 as a new assembly factor for human respiratory complex I with a possible role in the delivery of one or more Fe/S clusters to complex I subunits.[Ind1] PMID: 19752196

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  • 相關(guān)疾?。?/div>
    Mitochondrial complex I deficiency (MT-C1D)
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Mrp/NBP35 ATP-binding proteins family
  • 組織特異性：
    Highest expression in liver and kidney. expressed at significant levels in small intestine and brain (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20278

    OMIM: 252010

    KEGG: hsa:80224

    STRING: 9606.ENSP00000281081

    UniGene: Hs.288981