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  4. OIP5 Antibody, HRP conjugated

OIP5 Antibody, HRP conjugated

  • 中文名稱：
    OIP5兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA016316LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) OIP5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OIP5
  • 別名：
    OIP5 antibody; MIS18B antibody; Protein Mis18-beta antibody; Cancer/testis antigen 86 antibody; CT86 antibody; Opa-interacting protein 5 antibody; OIP-5 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein Mis18-beta protein (1-229AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
  • 基因功能參考文獻(xiàn)：
    1. LncRNA OIP5-AS1 suppressed cell viability, promoted radio-induced apoptosis, and enhanced the radiosensitivity of CRC cells by regulating DYRK1A expression through miR-369-3p. PMID: 29773344
    2. LncRNA OIP5-AS1 modulated the expression of Bcl-2 by targeting miR-448 in lung adenocarcinoma cells. PMID: 29247949
    3. interaction network might function as an oncogene in bladder cancer progression PMID: 28843748
    4. The authors demonstrate that CDK1 controls Mis18 complex recruitment to centromeres by regulating oligomerization of M18BP1 through the Mis18alpha:Mis18beta scaffold. PMID: 28059702
    5. High OIP5 expression is associated with bladder cancer. PMID: 28752236
    6. Mitofusin 2 knockdown altered Neisseria gonorrhoeae opacity-associated-interacting protein 5 (OIP5) expression. PMID: 29034772
    7. These findings suggest that OIP5 may be involved in hepatocellular carcinoma (HCC) growth and metastasis and that miR-15b-5p inhibits OIP5-mediated oncogenic signaling in HCC. PMID: 28184024
    8. the Mis18 complex contains dual CENP-C recognition motifs that are combinatorially required to generate robust centromeric localization that leads to CENP-A deposition PMID: 27239045
    9. OIP5 over-expression inhibited hsa-miR-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene in promoting breast cancer progression. PMID: 27916718
    10. Stable binding of Mis18alpha-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A deposition. PMID: 26942680
    11. Over-expression of OIP5 was observed in breast tumors. PMID: 26107214
    12. Mis18beta binds with and specifies the centromere localization of HJURP. PMID: 24519934
    13. this study showed betaTrCP-mediated regulation of Mis18beta stability is a mechanism to restrict centromere function of Mis18 complex from late mitosis to early G1 phase. PMID: 24269809
    14. expression of AURKC, OIP5, PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia, myelodysplastic syndrome and healthy controls in a gender-dependent manner PMID: 23292864
    15. OIP5 expression was significantly associated with poor prognosis of lung and esophageal cancer patients PMID: 22129094
    16. These results indicate that knockdown of OIP5 may induce apoptosis in cancer cells. PMID: 20510019
    17. Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta, and M18BP1, the complex of which is accumulated specifically at the telophase-G1 centromere, are identified.[Mis18alpha, Mis18beta, M18BP1] PMID: 17199038

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
  • 蛋白家族：
    Mis18 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20300

    OMIM: 606020

    KEGG: hsa:11339

    STRING: 9606.ENSP00000220514

    UniGene: Hs.661645