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  4. OXR1 Antibody

OXR1 Antibody

  • 中文名稱：
    OXR1兔多克隆抗體
  • 貨號：
    CSB-PA971107
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using OXR1 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) OXR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OXR1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human OXR1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be involved in protection from oxidative damage.
  • 基因功能參考文獻：
    1. OXR1 may act as a sensor of cellular oxidative stress to regulate the transcriptional networks required to detoxify reactive oxygen species and modulate cell cycle and apoptosis. PMID: 26616534
    2. Oxr1 serves as a potential therapeutic target for ALS and other neurodegenerative disorders characterized by TDP-43 or FUS pathology. PMID: 25792726
    3. OXR1 upregulates the expression of antioxidant genes via the p21 signaling pathway to suppress hydrogen peroxide-induced oxidative stress and maintain mtDNA integrity. PMID: 25236744
    4. The protein segment encoded by exon 8 plays an important role in the anti-oxidative function of the human OXR1 protein. PMID: 22873401
    5. Data show that human and yeast oxidation resistance 1 (OXR1) genes are induced by heat and oxidative stress and that their proteins localize to the mitochondria and function to protect against oxidative damage. PMID: 15060142
    6. human OXR1 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance. PMID: 17391516

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  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    OXR1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15822

    OMIM: 605609

    KEGG: hsa:55074

    STRING: 9606.ENSP00000405424

    UniGene: Hs.127286