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  4. PAGE4 Antibody

PAGE4 Antibody

  • 中文名稱(chēng)：
    PAGE4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA900712
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA900712(PAGE4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PAGE4
  • 別名：
    PAGE4 antibody; GAGEC1 antibody; JM27P antigen family member 4 antibody; PAGE-4 antibody; G antigen family C member 1 antibody; PAGE-1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human PAGE4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN. Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway.
  • 基因功能參考文獻(xiàn)：
    1. phosphorylation of PAGE4 leads to conformational shifts PMID: 26242913
    2. PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1. PMID: 24559171
    3. Data suggest that disrupting prostate-associated gene 4 (PAGE4)/c-Jun interaction using small molecules could be a novel strategy to treat prostate cancer. PMID: 24263171
    4. Dysregulation of epithelial PAGE4 modulates AR signaling. PMID: 22885105
    5. PAGE4 is a highly intrinsically disordered protein with an anti-apoptotic function PMID: 21357425
    6. PAGE4 mRNA is expressed only in the cytoplasm of epithelial cells of normal and prostate-cancer specimens PMID: 12489849
    7. These results suggest that GAGE gene might have an important role in the development and progression of intestinal type of stomach cancer and the detection of GAGE mRNA may be eligible to the panel of molecular markers for aggressive behavior. PMID: 15362791

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Mitochondrion.
  • 蛋白家族：
    GAGE family
  • 組織特異性：
    Expressed at basal lvels in the adult normal prostate gland but is highly up-regulated in the fetal prostate and prostate cancer cells. Preferentially expressed in normal male and female reproductive tissues, testis, fallopian tube, uterus, and placenta,
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4108

    OMIM: 300287

    KEGG: hsa:9506

    STRING: 9606.ENSP00000218068

    UniGene: Hs.441038