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PAIP2 Antibody, FITC conjugated

  • 中文名稱：
    PAIP2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA859027LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PAIP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PAIP2
  • 別名：
    PABP-interacting protein 2 antibody; PAIP-2 antibody; PAIP2 antibody; PAIP2_HUMAN antibody; poly(A) binding protein interacting protein 2 antibody; Poly(A)-binding protein-interacting protein 2 antibody; Polyadenylate-binding protein-interacting protein 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Polyadenylate-binding protein-interacting protein 2 protein (1-127AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
  • 基因功能參考文獻：
    1. Paip2 is a host antiviral restriction factor antagonized by PABP accumulation in HCMV-infected cells PMID: 23964095
    2. Role of PAIP2 in modulation of GLUT5 mRNA stability. PMID: 12820898
    3. PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis PMID: 15175342
    4. The turnover of Paip2 in the cell is mediated by EDD and is regulated by PABP. PMID: 16601676
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    PAIP2 family
  • 組織特異性：
    Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17970

    OMIM: 605604

    KEGG: hsa:51247

    STRING: 9606.ENSP00000265192

    UniGene: Hs.396644