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  4. PCBD1 Antibody, FITC conjugated

PCBD1 Antibody, FITC conjugated

  • 中文名稱：
    PCBD1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA017514LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PCBD1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PCBD1
  • 別名：
    4 alpha hydroxy tetrahydropterin dehydratase antibody; 4-alpha-hydroxy-tetrahydropterin dehydratase antibody; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; DCoH antibody; Dimerization cofactor of hepatic nuclear factor 1 alpha antibody; Dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; Dimerization cofactor of hepatocyte nuclear factor 1-alpha antibody; Dimerization cofactor of HNF1 antibody; Dimerizing cofactor for HNF1 antibody; PCBD 1 antibody; PCBD antibody; PCBD1 antibody; PCD antibody; Phenylalanine hydroxylase stimulating protein antibody; Phenylalanine hydroxylase-stimulating protein antibody; PHS antibody; PHS_HUMAN antibody; Pterin 4 alpha carbinolamine dehydratase antibody; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) antibody; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha antibody; Pterin carbinolamine dehydratase antibody; Pterin-4-alpha-carbinolamine dehydratase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Pterin-4-alpha-carbinolamine dehydratase protein (2-104AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription.
  • 基因功能參考文獻：
    1. We provide the first genetic evidence that PCBD1 mutations can cause early-onset nonautoimmune diabetes with features similar to dominantly inherited HNF1A-diabetes. PMID: 24848070
    2. Coactivator of the HNFB1 (HNF1 homeobox B)-mediated transcription is necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule PMID: 24204001
    3. Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha. PMID: 9092652
    4. variants of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH/PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function PMID: 11668623
    5. Data reveal DCoH/HNF-1 alpha expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase, the key enzyme for pigmentation, as a new transcriptional target. PMID: 12565907
    6. Albumin colocalized together with its transcription factor PCD/DCoH/HNF-1alpha in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium. PMID: 15740590
    7. Properties of dehydratase/DCoHalpha are consistent with hypothesis that activity of this isozyme could account for relatively mild symptoms reported for patients with a defect in dehydratase/DCoH PMID: 16423549

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  • 相關疾?。?/div>
    Hyperphenylalaninemia, BH4-deficient, D (HPABH4D)
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Pterin-4-alpha-carbinolamine dehydratase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8646

    OMIM: 126090

    KEGG: hsa:5092

    STRING: 9606.ENSP00000299299

    UniGene: Hs.3192