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  4. PDE1C Antibody, FITC conjugated

PDE1C Antibody, FITC conjugated

  • 中文名稱：
    PDE1C兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA623901LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PDE1C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    5''-cyclic nucleotide phosphodiesterase 1C antibody; Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C antibody; Calcium/calmodulin-dependent 3'' antibody; Cam PDE 1C antibody; Cam-PDE 1C antibody; hCam 3 antibody; hCam-3 antibody; HCAM3 antibody; HSPDE1C1A antibody; Human 3'5' cyclic nucleotide Phosphodiesterase antibody; PDE 1C antibody; Pde1c antibody; PDE1C_HUMAN antibody; Phosphodiesterase 1C antibody; Phosphodiesterase 1C calmodulin dependent antibody; Phosphodiesterase 1C calmodulin dependent 70kDa antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C protein (542-634AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
  • 基因功能參考文獻：
    1. PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro. PMID: 25620587
    2. PDE1C is an important regulator of SMC proliferation, migration, and neointimal hyperplasia, in part through modulating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1. PMID: 25608528
    3. PDE1C levels decreased in all conditions that inhibited proliferation PMID: 16455054
    4. PDE1C1 is expressed at high levels in human cardiac myocytes with an intracellular distribution distinct from that of PDE3A PMID: 17726023
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
  • 組織特異性：
    Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle. Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung. Also expressed at low levels in uterus and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8776

    OMIM: 602987

    KEGG: hsa:5137

    STRING: 9606.ENSP00000379496

    UniGene: Hs.143821