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  4. PDE6A Antibody

PDE6A Antibody

  • 中文名稱：
    PDE6A兔多克隆抗體
  • 貨號：
    CSB-PA2109ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA2109ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA2109ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PDE6A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PDE6A
  • 別名：
    5''-cyclic phosphodiesterase subunit alpha antibody; CGPR A antibody; GMP PDE alpha antibody; GMP-PDE alpha antibody; PDE 6 alpha antibody; PDE 6A antibody; PDE V B1 antibody; PDE V-B1 antibody; PDE6A antibody; PDE6A_HUMAN antibody; PDEA antibody; Phosphodiesterase 6 alpha antibody; Phosphodiesterase 6A alpha subunit antibody; Phosphodiesterase 6A antibody; Phosphodiesterase 6A cGMP specific rod alpha antibody; Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha antibody; Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit antibody; Rod cGMP-specific 3'' antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Rod cGMP-specific 3\',5\'-cyclic phosphodiesterase subunit alpha protein (656-860AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶點詳情

  • 功能：
    This protein participates in processes of transmission and amplification of the visual signal.
  • 基因功能參考文獻(xiàn)：
    1. this is the first phenotypic description of arRP due to homozygous IVS6+1G>A mutations in PDE6A and these seem here to be associated with severe RP leading to early extinction of rod responses as well as reduced macular function. PMID: 27820873
    2. report two splice acceptor site variations in PDE6A in consanguineous Pakistani families who manifested cardinal symptoms of autosomal recessive retinitis pigmentosa PMID: 26321862
    3. analysis of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6 PMID: 23033484
    4. the p.Val685Met mutation in PDE6A causes retinal degeneration in humans PMID: 21039428
    5. Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent. PMID: 20940301
    6. full transcriptional activity of the PDE6A gene requires both Nrl and Crx PMID: 15001570
    7. Homozygous single base pair change; c.889C->T, single base pair insertion; c.2218-2219insT, and single base pair substitution in the splice acceptor site; IVS10-2A->G in each of three families. PMID: 17110911

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  • 相關(guān)疾病：
    Retinitis pigmentosa 43 (RP43)
  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8785

    OMIM: 180071

    KEGG: hsa:5145

    STRING: 9606.ENSP00000255266

    UniGene: Hs.567314