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  4. PDZD2 Antibody

PDZD2 Antibody

  • 中文名稱：
    PDZD2兔多克隆抗體
  • 貨號：
    CSB-PA826920
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using PDZD2 antibody.
    • Immunofluorescence analysis of HepG2 cells, using PDZD2 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PDZD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PDZD2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human PDZD2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. we systematically evaluating RCC risk-associated SNPs indentified from previous GWAS in a Chinese population, finding that one SNP located in PDZD2 and two SNPs located in ITPR2 were ccRCC-risk associated in Chinese population. PMID: 26918600
    2. The DNA copy number variations disrupt PDZD2 and GOLPH3 genes predominantly expressed in placenta, and it may represent a novel risk factor for recurrent miscarriage. PMID: 24827138
    3. This study does not support the association of PDZD2, GOLPH3, and MTMR12 genes with schizophrenia. PMID: 21451436
    4. the first reported multi-PDZ protein that is processed by proteolytic cleavage to generate a secreted peptide containing two PDZ domains PMID: 12671685
    5. The mitogenic effect of secreted PDZD2 was concentration-dependent, and was associated with a slight inhibition of the insulin promoter activity at high sPDZD2 concentrations. PMID: 16413998
    6. Results show that a novel pancreatic developmental factor, PDZD2, is sufficient to promote the proliferation of human fetal PPCs while limiting differentiation of ICCs into islet/endocrine cells. PMID: 18037333
    7. sPDZD2 sensitized mutant p53-positive DU145 cells and wild-type p53-positive MCF-7 cells to apoptosis induction through genotoxic stress imposed by sub-lethal concentration of hydrogen peroxide PMID: 18639375
    8. PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization. PMID: 19046020

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Endoplasmic reticulum.; [Processed PDZ domain-containing protein 2]: Secreted.
  • 組織特異性：
    Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18486

    OMIM: 610697

    KEGG: hsa:23037

    STRING: 9606.ENSP00000282493

    UniGene: Hs.481819