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  4. PES1 Antibody, FITC conjugated

PES1 Antibody, FITC conjugated

  • 中文名稱：
    PES1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA017791LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PES1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PES1
  • 別名：
    FLJ43790 antibody; Homo sapiens pescadillo mRNA complete cds antibody; PES antibody; PES 1 antibody; pes1 antibody; PESC_HUMAN antibody; Pescadillo (zebrafish) homolog 1 containing BRCT domain antibody; Pescadillo homolog 1 antibody; Pescadillo homolog 1 containing BRCT domain (zebrafish) antibody; Pescadillo homolog antibody; Pescadillo ribosomal biogenesis factor 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Pescadillo homolog protein (378-588AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
  • 基因功能參考文獻(xiàn)：
    1. posttranslational modification of PES1 by SUMOylation may serve as a key factor that regulates the function of PES1 in vivo PMID: 27409667
    2. PES1 may play an important role in development of gastric cancer. PMID: 26423399
    3. PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression. PMID: 24376209
    4. these results uncover a potential role of PES1 in chemoresistance by regulating DNA damage response in colorectal cancer cells. PMID: 23333390
    5. Upstream of c-Jun, it was revealed that c-Jun NH2-terminal kinases (JNK) is essential for controlling PES1 expression PMID: 22860098
    6. expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer PMID: 22820289
    7. The physical interaction between B23 and PES1 implies that they may participate in ribosome biogenesis in a protein complex. PMID: 20011973
    8. pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment. PMID: 19764998
    9. Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them. PMID: 15273728
    10. RRB1 interacts with YPH1 (yeast pescadillo homologue 1) and other members of the Yph1 complex PMID: 15467761
    11. Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). PMID: 16043514
    12. Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association. PMID: 17353269

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  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome.
  • 蛋白家族：
    Pescadillo family
  • 組織特異性：
    Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8848

    OMIM: 605819

    KEGG: hsa:23481

    STRING: 9606.ENSP00000346725

    UniGene: Hs.517543