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  4. PFKL Antibody, HRP conjugated

PFKL Antibody, HRP conjugated

  • 中文名稱：
    PFKL兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA017821LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PFKL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PFKL antibody; ATP-dependent 6-phosphofructokinase antibody; liver type antibody; ATP-PFK antibody; PFK-L antibody; EC 2.7.1.11 antibody; 6-phosphofructokinase type B antibody; Phosphofructo-1-kinase isozyme B antibody; PFK-B antibody; Phosphohexokinase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-dependent 6-phosphofructokinase, liver type protein (229-479AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.
  • 基因功能參考文獻：
    1. Liver PFK1 isoform assembles into filaments in a tetramer- and substrate-dependent manner,organizing isoform specific glucose metabolism in cells. PMID: 28646105
    2. findings showed glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells PMID: 22923583
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade "E" sub-subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8876

    OMIM: 171860

    KEGG: hsa:5211

    STRING: 9606.ENSP00000269848

    UniGene: Hs.255093