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  4. PFKM Antibody, HRP conjugated

PFKM Antibody, HRP conjugated

  • 中文名稱：
    PFKM兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA017822LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PFKM Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    6 Phosphofructokinase Muscle Type antibody; 6-phosphofructokinase antibody; 6-phosphofructokinase muscle type antibody; EC 2.7.1.1 antibody; EC 2.7.1.11 antibody; GSD7 antibody; K6PF_HUMAN antibody; MGC8699 antibody; muscle type antibody; PFK; muscle type antibody; PFK-A antibody; PFKA antibody; PFKL antibody; PFKM antibody; PFKP antibody; PFKX antibody; Phosphofructo 1 Kinase Isozyme A antibody; Phosphofructo-1-kinase isozyme A antibody; Phosphofructokinase 1 antibody; Phosphofructokinase M antibody; Phosphofructokinase; muscle antibody; Phosphofructokinase; muscle type antibody; Phosphofructokinase; polypeptide X antibody; Phosphofructokinase-M antibody; Phosphohexokinase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-dependent 6-phosphofructokinase, muscle type protein (166-334AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  • 基因功能參考文獻(xiàn)：
    1. KLK6 may be the key protease involved in the proteolytic modification of PFK-M. PMID: 29563071
    2. characterize three PFK1 mutations and show they have distinct effects on allosteric regulation of PFKP activity and lactate production. PMID: 25985179
    3. Gene-based analysis identified an association between breast cancer and the phosphofructokinase-muscle (PFKM) gene on chromosome 12q13.11 that met the genome-wide gene-based threshold of 2.5 x 10(-6). PMID: 24493630
    4. insulin/phosphofructokinase (PFKM), overlaps with an expression quantitative trait loci PMID: 24306210
    5. Asp(543)Ala, a naturally occurring Tarui disease-causing mutation in the activating binding site, causes an increased efficacy of ATP at the inhibitory allosteric binding site. PMID: 22995305
    6. Molecular genetic findings demonstrated the absence of specific genotype-phenotype correlations in PFKM gene mutations. PMID: 22133655
    7. eukaryotic Pfk did not evolve from prokaryotic ancestors, reciprocal linkage of functionally opposed allosteric binding sites must have developed independently in prokaryotic and eukaryotic Pfk (convergent evolution). PMID: 22474333
    8. Posttranslational modification of PFK1 enzyme might be the pivotal factor of deregulated glycolytic flux in tumors PMID: 21573193
    9. Data indicate that substitution of residue at the citrate-binding site (D591V) of PFK-M resulted in the complete loss of activity. PMID: 21124851
    10. Glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFK-L over the M and P isoforms. PMID: 20483646
    11. Identification of novel PFK-M transcripts in the testis and embryo. PMID: 15020257
    12. Two phosphofructokinase (PFK) chimeras were constructed by exchanging the N- and C-terminal halves of the mammalian M- and C-type isozymes. PMID: 17544406

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  • 相關(guān)疾病：
    Glycogen storage disease 7 (GSD7)
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade "E" sub-subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8877

    OMIM: 232800

    KEGG: hsa:5213

    STRING: 9606.ENSP00000345771

    UniGene: Hs.75160